4BPW
Crystal structure of human primase bound to UTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | DNA PRIMASE SMALL SUBUNIT | polymer | 423 | 50108.0 | 2 | UniProt (P49642) Pfam (PF01896) | HOMO SAPIENS (HUMAN) | PRIMASE, DNA PRIMASE 49 KDA SUBUNIT, P49 |
| 2 | B, D (B, D) | DNA PRIMASE LARGE SUBUNIT | polymer | 253 | 29782.2 | 2 | UniProt (P49643) | HOMO SAPIENS (HUMAN) | PRIMASE, DNA PRIMASE 58 KDA SUBUNIT, P58 |
| 3 | E, I (A, C) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | F, G, J, K (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | H, L (A, C) | URIDINE 5'-TRIPHOSPHATE | non-polymer | 484.1 | 2 | Chemie (UTP) |
Sequence modifications
A, C: 1 - 420 (UniProt: P49642)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Thr -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ala 72 | Lys 72 | engineered mutation |
| Ala 73 | Met 73 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 159780.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1196.3 | |
| All* | Total formula weight | 160976.7 |
