4BKS

von Hippel Lindau protein:ElonginB:ElonginC complex, in complex with (2S,4R)-1-ethanoyl-N-[[4-(1,3-oxazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, J	TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2	polymer	104	11852.4	2	UniProt (Q15370) Pfam (PF00240) In PDB	HOMO SAPIENS (HUMAN)	ELONGIN 18 KDA SUBUNIT, ELONGIN-B, ELOB, RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT B, SIII P18, ELONGINB1-104
2	B, E, H, K	TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1	polymer	97	10974.6	4	UniProt (Q15369) Pfam (PF03931) In PDB	HOMO SAPIENS (HUMAN)	ELONGIN 15 KDA SUBUNIT, ELONGIN-C, ELOC, RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT C, SIII P15, ELONGINC
3	C, F, I, L	VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR	polymer	162	18806.3	4	UniProt (P40337) Pfam (PF01847) Pfam (PF17211) In PDB	HOMO SAPIENS (HUMAN)	PROTEIN G7, PVHL, PVHL54-213
4	D, G	TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2	polymer	104	11748.4	2	UniProt (Q15370) Pfam (PF00240) In PDB	HOMO SAPIENS (HUMAN)	ELONGIN 18 KDA SUBUNIT, ELONGIN-B, ELOB, RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT B, SIII P18, ELONGINB1-104
5	C, F, I, L	(2S,4R)-1-ethanoyl-N-[[4-(1,3-oxazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide	non-polymer		329.4	4	Chemie (X6C)
6	C, L	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
7		water	water		18.0	604	Chemie (HOH)

Sequence modifications

B, E, H, K: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	expression tag

C, F, I, L: 54 - 213 (UniProt: P40337)

PDB	External Database	Details
Gly 52	-	expression tag
Ser 53	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	166325.1
Non-Polymers*	Number of molecules	6
	Total formula weight	1435.5
All*	Total formula weight	167760.6

*Water molecules are not included.