4BJX
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | BROMODOMAIN-CONTAINING PROTEIN 4 | polymer | 153 | 17939.5 | 1 | UniProt (O60885) Pfam (PF00439) | HOMO SAPIENS (HUMAN) | PROTEIN HUNK1, BRD4 |
| 2 | B (A) | 4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl]benzoic acid | non-polymer | 434.9 | 1 | Chemie (73B) | |||
| 3 | C (A) | water | water | 18.0 | 297 | Chemie (HOH) |
Sequence modifications
A: 44 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Gly 31 | - | expression tag |
| Ser 32 | - | expression tag |
| Ser 33 | - | expression tag |
| His 34 | - | expression tag |
| His 35 | - | expression tag |
| His 36 | - | expression tag |
| His 37 | - | expression tag |
| His 38 | - | expression tag |
| His 39 | - | expression tag |
| Ser 40 | - | expression tag |
| Ser 41 | - | expression tag |
| Ser 42 | - | expression tag |
| Met 43 | - | expression tag |
| Gln 169 | - | expression tag |
| Glu 170 | - | expression tag |
| Leu 171 | - | expression tag |
| Val 172 | - | expression tag |
| Val 173 | - | expression tag |
| Thr 174 | - | expression tag |
| Ile 175 | - | expression tag |
| Pro 176 | - | expression tag |
| Asn 177 | - | expression tag |
| Ser 178 | - | expression tag |
| His 179 | - | expression tag |
| Lys 180 | - | expression tag |
| Lys 181 | - | expression tag |
| Gly 182 | - | expression tag |
| Ala 183 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17939.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 434.9 | |
| All* | Total formula weight | 18374.4 |
