4BJX

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	BROMODOMAIN-CONTAINING PROTEIN 4	polymer	153	17939.5	1	UniProt (O60885) Pfam (PF00439) In PDB	HOMO SAPIENS (HUMAN)	PROTEIN HUNK1, BRD4
2	A	4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl]benzoic acid	non-polymer		434.9	1	Chemie (73B)
3		water	water		18.0	297	Chemie (HOH)

Sequence modifications

A: 44 - 168 (UniProt: O60885)

PDB	External Database	Details
Gly 31	-	expression tag
Ser 32	-	expression tag
Ser 33	-	expression tag
His 34	-	expression tag
His 35	-	expression tag
His 36	-	expression tag
His 37	-	expression tag
His 38	-	expression tag
His 39	-	expression tag
Ser 40	-	expression tag
Ser 41	-	expression tag
Ser 42	-	expression tag
Met 43	-	expression tag
Gln 169	-	expression tag
Glu 170	-	expression tag
Leu 171	-	expression tag
Val 172	-	expression tag
Val 173	-	expression tag
Thr 174	-	expression tag
Ile 175	-	expression tag
Pro 176	-	expression tag
Asn 177	-	expression tag
Ser 178	-	expression tag
His 179	-	expression tag
Lys 180	-	expression tag
Lys 181	-	expression tag
Gly 182	-	expression tag
Ala 183	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	17939.5
Non-Polymers*	Number of molecules	1
	Total formula weight	434.9
All*	Total formula weight	18374.4

*Water molecules are not included.