4BCP
Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | CYCLIN-DEPENDENT KINASE 2 | polymer | 300 | 34200.6 | 2 | UniProt (P24941) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | CELL DIVISION PROTEIN KINASE 2, P33 PROTEIN KINASE |
| 2 | B, D | CYCLIN-A2 | polymer | 262 | 30053.7 | 2 | UniProt (P20248) Pfam (PF00134) Pfam (PF02984) In PDB | HOMO SAPIENS (HUMAN) | CYCLIN-A |
| 3 | A, C | 2-[[3-(1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile | non-polymer | 420.5 | 2 | Chemie (T3C) | |||
| 4 | B, D | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | B, D | MONOTHIOGLYCEROL | non-polymer | 108.2 | 3 | Chemie (SGM) | |||
| 6 | water | water | 18.0 | 363 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 128508.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1357.7 | |
| All* | Total formula weight | 129866.3 |
