4BCK
Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C (A, C) | CYCLIN-DEPENDENT KINASE 2 | polymer | 300 | 34200.6 | 2 | UniProt (P24941) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | CELL DIVISION PROTEIN KINASE 2, P33 PROTEIN KINASE |
2 | B, D (B, D) | CYCLIN-A2 | polymer | 262 | 30053.7 | 2 | UniProt (P20248) Pfam (PF00134) Pfam (PF02984) | HOMO SAPIENS (HUMAN) | CYCLIN-A |
3 | E, G (A, C) | 3-[[5-cyano-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]benzenesulfonamide | non-polymer | 401.5 | 2 | Chemie (T3E) | |||
4 | F (A) | MONOTHIOGLYCEROL | non-polymer | 108.2 | 1 | Chemie (SGM) | |||
5 | H, I, J, K (A, B, C, D) | water | water | 18.0 | 629 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 128508.6 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 911.1 | |
All* | Total formula weight | 129419.7 |