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4BCK

Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, C
(A, C)
CYCLIN-DEPENDENT KINASE 2polymer30034200.62UniProt (P24941)
Pfam (PF00069)
HOMO SAPIENS (HUMAN)CELL DIVISION PROTEIN KINASE 2, P33 PROTEIN KINASE
2B, D
(B, D)
CYCLIN-A2polymer26230053.72UniProt (P20248)
Pfam (PF00134)
Pfam (PF02984)
HOMO SAPIENS (HUMAN)CYCLIN-A
3E, G
(A, C)
3-[[5-cyano-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]benzenesulfonamidenon-polymer401.52Chemie (T3E)
4F
(A)
MONOTHIOGLYCEROLnon-polymer108.21Chemie (SGM)
5H, I, J, K
(A, B, C, D)
waterwater18.0629Chemie (HOH)
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
PDBExternal DatabaseDetails
Gly -1-expression tag
Ser 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight128508.6
Non-Polymers*Number of molecules3
Total formula weight911.1
All*Total formula weight129419.7
*Water molecules are not included.

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PDB entries from 2024-11-06

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