4BCG
Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | CYCLIN-DEPENDENT KINASE 9 | polymer | 331 | 38054.1 | 1 | UniProt (P50750) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | C-2K, CELL DIVISION CYCLE 2-LIKE PROTEIN KINASE 4, CELL DIVISION PROTEIN KINASE 9, SERINE/THREONINE-PROTEIN KINASE PITALRE, TAT-ASSOCIATED KINASE COMPLEX CATALYTIC SUBUNIT |
2 | B | CYCLIN-T1 | polymer | 260 | 30119.4 | 1 | UniProt (O60563) Pfam (PF00134) Pfam (PF21797) In PDB | HOMO SAPIENS (HUMAN) | CYCT1, CYCLIN-T |
3 | A | 2-[[3-(1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile | non-polymer | 420.5 | 1 | Chemie (T3C) | |||
4 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
5 | water | water | 18.0 | 16 | Chemie (HOH) |
Sequence modifications
A: 2 - 330 (UniProt: P50750)
B: 2 - 259 (UniProt: O60563)
PDB | External Database | Details |
---|---|---|
Gly 0 | - | expression tag |
Pro 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 0 | - | expression tag |
Pro 1 | - | expression tag |
Arg 77 | Gln 77 | engineered mutation |
Gly 96 | Glu 96 | engineered mutation |
Leu 241 | Phe 241 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 68173.5 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 604.7 | |
All* | Total formula weight | 68778.2 |