4B6L
Discovery of Oral Polo-Like Kinase (PLK) Inhibitors with Enhanced Selectivity Profile using Residue Targeted Drug Design
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | SERINE/THREONINE-PROTEIN KINASE PLK3 | polymer | 281 | 32218.2 | 1 | UniProt (Q9H4B4) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | POLO-LIKE KINASE 3, CYTOKINE-INDUCIBLE SERINE/THREONINE-PROTEIN KINASE, FGF-INDUCIBLE KINASE, POLO-LIKE KINASE 3, PLK-3, PROLIFERATION-RELATED KINASE |
| 2 | B (A) | 4-[[(4R)-5-cyclopentyl-4-ethyl-3a,4-dihydro-3H-[1,2,4]triazolo[4,3-f]pteridin-7-yl]amino]-N-cyclopropyl-3-methoxy-benzamide | non-polymer | 476.6 | 1 | Chemie (9ZP) | |||
| 3 | C (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | D (A) | water | water | 18.0 | 228 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32218.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 572.6 | |
| All* | Total formula weight | 32790.9 |
