4B4S
Crystal Structure of a pro-survival Bcl-2:Bim BH3 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | BCL-2-LIKE PROTEIN 10 | polymer | 175 | 19499.0 | 1 | UniProt (Q9HD36) Pfam (PF00452) | HOMO SAPIENS (HUMAN) | BCL2-L-10, ANTI-APOPTOTIC PROTEIN NRH, APOPTOSIS REGULATOR BCL-B |
| 2 | B (B) | BCL-2-LIKE PROTEIN 11 | polymer | 28 | 3418.8 | 1 | UniProt (O43521) Pfam (PF08945) | HOMO SAPIENS (HUMAN) | BCL2-L-11, BCL2-INTERACTING MEDIATOR OF CELL DEATH |
| 3 | C (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 88 | Chemie (HOH) |
Sequence modifications
A: 1 - 166 (UniProt: Q9HD36)
B: 51 - 76 (UniProt: O43521)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Glu 167 | - | expression tag |
| Asn 168 | - | expression tag |
| Leu 169 | - | expression tag |
| Tyr 170 | - | expression tag |
| Phe 171 | - | expression tag |
| Gln 172 | - | expression tag |
| Ser 19 | Cys 20 | engineered mutation |
| Ser 127 | Cys 128 | engineered mutation |
| Ser 156 | Cys 157 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 49 | - | expression tag |
| Ser 50 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 22917.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 194.2 | |
| All* | Total formula weight | 23112.1 |
