4B3O
Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | REVERSE TRANSCRIPTASE/RIBONUCLEASE H | polymer | 560 | 64424.8 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB | HUMAN IMMUNODEFICIENCY VIRUS 1 (HIV-1) | REVERSE TRANSCRIPTASE, EXORIBONUCLEASE H, P66 RT, REVERSE TRANSCRIPTASE P66 SUBUNIT |
2 | B | P51 RT | polymer | 441 | 51384.0 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB | HUMAN IMMUNODEFICIENCY VIRUS 1 (HIV-1) | REVERSE TRANSCRIPTASE, REVERSE TRANSCRIPTASE P51 SUBUNIT |
3 | D | 5'-D(*CP*GP*TP*AP*TP*GP*CP*CP*TP*AP*TP*AP*GP*TP *TP*AP*TP*TP*GP*TP*GP*GP*CP*C)-3' | polymer | 24 | 7366.7 | 1 | SYNTHETIC CONSTRUCT | PRIMER DNA | |
4 | R | 5'-R(*AP*UP*GP*AP*3DRP*GP*GP*CP*CP*AP*CP*AP*AP*UP*AP *AP*CP*UP*AP*UP*AP*GP*GP*CP*AP*UP*A)-3' | polymer | 27 | 8539.2 | 1 | SYNTHETIC CONSTRUCT | TEMPLATE RNA | |
5 | A | (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE | non-polymer | 315.7 | 1 | Chemie (EFZ) | |||
6 | D, R | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) |
Sequence modifications
A: 1 - 560 (UniProt: P04585)
B: 1 - 440 (UniProt: P04585)
PDB | External Database | Details |
---|---|---|
Gly 68 | Ser 655 | engineered mutation |
Lys 83 | Arg 670 | engineered mutation |
Val 411 | Ile 998 | engineered mutation |
Ser 447 | Asn 1034 | engineered mutation |
Lys 461 | Arg 1048 | engineered mutation |
His 483 | Tyr 1070 | engineered mutation |
Ile 559 | Val 1146 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 0 | - | expression tag |
Gly 68 | Ser 655 | engineered mutation |
Lys 83 | Arg 670 | engineered mutation |
Val 411 | Ile 998 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 131714.8 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 395.8 | |
All* | Total formula weight | 132110.6 |