4B1D
New Aminoimidazoles as BACE-1 Inhibitors: From Rational Design to Ab- lowering in Brain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | BETA-SECRETASE 1 | polymer | 388 | 43198.7 | 1 | UniProt (P56817) Pfam (PF00026) In PDB | HOMO SAPIENS (HUMAN) | ASPARTYL PROTEASE 2, ASP2, ASP 2, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, BETA-SITE APP CLEAVING ENZYME 1, MEMAPSIN-2, MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2 |
| 2 | A | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 3 | A | (2S)-2-(4-methoxy-3,5-dimethylphenyl)-5-methyl-2-(3-pyrimidin-5-ylphenyl)-2H-imidazol-4-amine | non-polymer | 385.5 | 1 | Chemie (6TG) | |||
| 4 | water | water | 18.0 | 271 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43198.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 503.5 | |
| All* | Total formula weight | 43702.3 |
