4B0G
Complex of Aurora-A bound to an Imidazopyridine-based inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | AURORA KINASE A | polymer | 283 | 32820.7 | 1 | UniProt (O14965) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | AURORA 2, AURORA/IPL1-RELATED KINASE 1, ARK-1, AURORA-RELATED KINASE 1, HARK1, BREAST TUMOR-AMPLIFIED KINASE, SERINE/THREONINE-PROTEIN KINASE 15, SERINE/THREONINE-PROTEIN KINASE 6, SERINE/THREONINE-PROTEIN KINASE AURORA-A |
| 2 | B (A) | 6-bromo-2-(1-methyl-1H-imidazol-5-yl)-7-{4-[(5-methyl-1,2-oxazol-3-yl)methyl]piperazin-1-yl}-1H-imidazo[4,5-b]pyridine | non-polymer | 457.3 | 1 | Chemie (VEK) | |||
| 3 | C, D, E, F (A) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | G (A) | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
A: 122 - 403 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Met 121 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32820.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 841.6 | |
| All* | Total formula weight | 33662.2 |
