4AYM

Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 3 P106A mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, E, F (A, B, E, F)	COMPLEMENT FACTOR H	polymer	125	14410.3	4	UniProt (P08603) Pfam (PF00084)	HOMO SAPIENS (HUMAN)	H FACTOR 1
2	C, D (C, D)	FACTOR H BINDING PROTEIN	polymer	270	29487.8	2	UniProt (Q19KF7) Pfam (PF20937) Pfam (PF08794)	NEISSERIA MENINGITIDIS MC58	LIPOPROTEIN GNA1870
3	G, H, I, J (A, B, C, D)	water	water		18.0	6	Chemie (HOH)

Sequence modifications

A, B, E, F: 321 - 443 (UniProt: P08603)

PDB	External Database	Details
Met 319	-	expression tag
Gly 320	-	expression tag
His 402	Tyr 402	variant

C, D: 73 - 320 (UniProt: Q19KF7)

PDB	External Database	Details
Met 61	-	expression tag
Gly 62	-	expression tag
Pro 63	-	expression tag
Asp 64	-	expression tag
Ser 65	-	expression tag
Asp 66	-	expression tag
Arg 67	-	expression tag
Leu 68	-	expression tag
Gln 69	-	expression tag
Gln 70	-	expression tag
Arg 71	-	expression tag
Arg 72	-	expression tag
Leu 321	-	expression tag
Glu 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag
Ala 106	Pro 65	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	116616.7
All*	Total formula weight	116616.7

*Water molecules are not included.