4AYI

Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis FHbp Variant 3 Wild type

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, E)	COMPLEMENT FACTOR H	polymer	125	14410.3	2	UniProt (P08603) Pfam (PF00084)	HOMO SAPIENS (HUMAN)	H FACTOR 1
2	B (D)	LIPOPROTEIN GNA1870 CCOMPND 7	polymer	270	29513.8	1	UniProt (Q19KF7) Pfam (PF20937) Pfam (PF08794)	NEISSERIA MENINGITIDIS MC58	FACTOR H BINDING PROTEIN
3	D (D)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
4	E, F, G (A, D, E)	water	water		18.0	204	Chemie (HOH)

Sequence modifications

A, E: 321 - 443 (UniProt: P08603)

PDB	External Database	Details
Met 319	-	expression tag
Gly 320	-	expression tag
His 402	Tyr 402	variant

D: 73 - 320 (UniProt: Q19KF7)

PDB	External Database	Details
Met 61	-	expression tag
Gly 62	-	expression tag
Pro 63	-	expression tag
Asp 64	-	expression tag
Ser 65	-	expression tag
Asp 66	-	expression tag
Arg 67	-	expression tag
Leu 68	-	expression tag
Gln 69	-	expression tag
Gln 70	-	expression tag
Arg 71	-	expression tag
Arg 72	-	expression tag
Leu 321	-	expression tag
Glu 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	58334.4
Non-Polymers*	Number of molecules	1
	Total formula weight	62.1
All*	Total formula weight	58396.5

*Water molecules are not included.