4AY6

Human O-GlcNAc transferase (OGT) in complex with UDP-5SGlcNAc and substrate peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANS FERASE 110 KDA SUBUNIT	polymer	723	80974.5	4	UniProt (O15294) Pfam (PF13424) Pfam (PF13414) Pfam (PF13844) In PDB	HOMO SAPIENS (HUMAN)	2.4.1.255, O-GLCNAC TRANSFERASE SUBUNIT P110, O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE 110 KDA SUBUNIT, OGT
2	E, F, G, H	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1	polymer	13	1309.4	4	UniProt (Q15750) In PDB	HOMO SAPIENS	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 1, TGF-BETA-ACTIVATED KINASE 1-BINDING PROTEIN 1, TAK1-BINDING PROTEIN 1
3	A, B, C, D	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
4	A, B, C, D	(2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate	non-polymer		623.4	4	Chemie (12V)

Sequence modifications

A, B, C, D: 313 - 1031 (UniProt: O15294)

PDB	External Database	Details
Gly 309	-	expression tag
Pro 310	-	expression tag
Gly 311	-	expression tag
Ser 312	-	expression tag

E, F, G, H: 1389 - 1401 (UniProt: Q15750)

PDB	External Database	Details
Dnp 1395	Ser 395	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	329135.6
Non-Polymers*	Number of molecules	8
	Total formula weight	2877.9
All*	Total formula weight	332013.6

*Water molecules are not included.