4AXA
Structure of PKA-PKB chimera complexed with (1S)-2-amino-1-(4- chlorophenyl)-1-(4-(1H-pyrazol-4-yl)phenyl)ethan-1-ol
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA | polymer | 351 | 40830.6 | 1 | UniProt (P00517) Pfam (PF00069) In PDB | BOS TAURUS (CATTLE) | PKA C-ALPHA |
2 | I | CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA | polymer | 20 | 2226.4 | 1 | UniProt (P61925) In PDB | HOMO SAPIENS | PKI-ALPHA, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR, MUSCLE/BRAIN ISOFORM |
3 | A | (2S)-2-(4-chlorophenyl)-2-hydroxy-2-[4-(1H-pyrazol-4-yl)phenyl]ethanaminium | non-polymer | 314.8 | 1 | Chemie (RKD) | |||
4 | water | water | 18.0 | 328 | Chemie (HOH) |
Sequence modifications
A: 0 - 350 (UniProt: P00517)
PDB | External Database | Details |
---|---|---|
Thr 104 | Val 105 | engineered mutation |
Ala 123 | Val 124 | engineered mutation |
Met 173 | Leu 174 | engineered mutation |
Lys 181 | Gln 182 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 43057.0 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 314.8 | |
All* | Total formula weight | 43371.8 |