4AWQ
Complex of HSP90 ATPase domain with tropane derived inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HEAT SHOCK PROTEIN HSP 90-ALPHA | polymer | 230 | 25800.9 | 2 | UniProt (P07900) Pfam (PF13589) | HOMO SAPIENS (HUMAN) | HEAT SHOCK 86 KDA, HSP 86, HSP86, RENAL CARCINOMA ANTIGEN NY-REN-38, HSP90 |
| 2 | C, D (A, B) | N-benzyl-6-[(3-endo)-3-{[(3-methoxy-2-methylphenyl)carbonyl]amino}-8-azabicyclo[3.2.1]oct-8-yl]pyridine-3-carboxamide | non-polymer | 484.6 | 2 | Chemie (592) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 267 | Chemie (HOH) |
Sequence modifications
A, B: 9 - 236 (UniProt: P07900)
| PDB | External Database | Details |
|---|---|---|
| Gly 7 | - | expression tag |
| Ser 8 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51601.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 969.2 | |
| All* | Total formula weight | 52571.0 |
