4AWP
Complex of HSP90 ATPase domain with tropane derived inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | HEAT SHOCK PROTEIN HSP 90-ALPHA | polymer | 230 | 25800.9 | 2 | UniProt (P07900) Pfam (PF13589) In PDB | HOMO SAPIENS (HUMAN) | HEAT SHOCK 86 KDA, HSP 86, HSP86, RENAL CARCINOMA ANTIGEN NY-REN-38, HSP90 |
| 2 | A, B | N-{(3-endo)-8-[5-(benzylcarbamoyl)pyridin-2-yl]-8-azabicyclo[3.2.1]oct-3-yl}-2,5-dimethylbenzene-1,4-dicarboxamide | non-polymer | 511.6 | 2 | Chemie (99A) | |||
| 3 | water | water | 18.0 | 279 | Chemie (HOH) |
Sequence modifications
A, B: 9 - 236 (UniProt: P07900)
| PDB | External Database | Details |
|---|---|---|
| Gly 7 | - | expression tag |
| Ser 8 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51601.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1023.2 | |
| All* | Total formula weight | 52625.0 |
