4AWO
Complex of HSP90 ATPase domain with tropane derived inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HEAT SHOCK PROTEIN HSP 90-ALPHA | polymer | 230 | 25800.9 | 2 | UniProt (P07900) Pfam (PF13589) | HOMO SAPIENS (HUMAN) | HSP90, HEAT SHOCK 86 KDA, HSP 86, HSP86, RENAL CARCINOMA ANTIGEN NY-REN-38 |
| 2 | C, D (A, B) | 5-[(2R)-butan-2-ylamino]-N-{(3-endo)-8-[5-(cyclopropylcarbonyl)pyridin-2-yl]-8-azabicyclo[3.2.1]oct-3-yl}-2-methylbenzene-1,4-dicarboxamide | non-polymer | 503.6 | 2 | Chemie (99B) PubChem (91885503) PubChem (98114329) PubChem (57748427) PubChem (57748689) PubChem (60147023) PubChem (67402879) PubChem (71301280) PubChem (98114328) PubChem (121595951) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 272 | Chemie (HOH) |
Sequence modifications
A, B: 9 - 236 (UniProt: P07900)
| PDB | External Database | Details |
|---|---|---|
| Gly 7 | - | expression tag |
| Ser 8 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51601.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1007.3 | |
| All* | Total formula weight | 52609.1 |
