4AQC
Triazolopyridine-based Inhibitor of Janus Kinase 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | TYROSINE-PROTEIN KINASE JAK2 | polymer | 301 | 35457.3 | 2 | UniProt (O60674) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | JANUS KINASE 2, JAK-2 |
| 2 | C, E (A, B) | 8-(4-methylsulfonylphenyl)-N-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine | non-polymer | 449.5 | 2 | Chemie (88A) | |||
| 3 | D, F, G, H, I (A, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 4 | J, K (A, B) | water | water | 18.0 | 442 | Chemie (HOH) |
Sequence modifications
A, B: 835 - 1132 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Gly 832 | - | expression tag |
| Ala 833 | - | expression tag |
| Met 834 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70914.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1379.4 | |
| All* | Total formula weight | 72294.0 |
