4AQC
Triazolopyridine-based Inhibitor of Janus Kinase 2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | TYROSINE-PROTEIN KINASE JAK2 | polymer | 301 | 35457.3 | 2 | UniProt (O60674) Pfam (PF07714) In PDB | HOMO SAPIENS (HUMAN) | JANUS KINASE 2, JAK-2 |
2 | A, B | 8-(4-methylsulfonylphenyl)-N-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine | non-polymer | 449.5 | 2 | Chemie (88A) | |||
3 | A, B | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
4 | water | water | 18.0 | 442 | Chemie (HOH) |
Sequence modifications
A, B: 835 - 1132 (UniProt: O60674)
PDB | External Database | Details |
---|---|---|
Gly 832 | - | expression tag |
Ala 833 | - | expression tag |
Met 834 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 70914.6 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1379.4 | |
All* | Total formula weight | 72294.0 |