4AP0
The mitotic kinesin Eg5 in complex with Mg-ADP and ispinesib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | KINESIN-LIKE PROTEIN KIF11 | polymer | 370 | 41209.7 | 4 | UniProt (P52732) Pfam (PF00225) | HOMO SAPIENS (HUMAN) | KINESIN-LIKE PROTEIN 1, KINESIN-LIKE SPINDLE PROTEIN HKSP, KINESIN-RELATED MOTOR PROTEIN EG5, EG5, THYROID RECEPTOR-INTERACTING PROTEIN 5, TR-INTERACTING PROTEIN 5, TRIP-5 |
| 2 | E, J, P, S (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 3 | F, K, Q, T (A, B, C, D) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 4 | Chemie (ADP) | |||
| 4 | G, H, L, M, N... (A, B, D) | CHLORIDE ION | non-polymer | 35.5 | 6 | Chemie (CL) | |||
| 5 | I, O, R, V (A, B, C, D) | ISPINESIB MESILATE | non-polymer | 517.1 | 4 | Chemie (G7X) | |||
| 6 | W, X, Y, Z (A, B, C, D) | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 368 (UniProt: P52732)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 164839.0 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 4087.0 | |
| All* | Total formula weight | 168926.0 |
