4AOI
Crystal structure of C-MET kinase domain in complex with 4-(3-((1H- pyrrolo(2,3-b)pyridin-3-yl)methyl)-(1,2,4)triazolo(4,3-b)(1,2,4) triazin-6-yl)benzonitrile
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HEPATOCYTE GROWTH FACTOR RECEPTOR | polymer | 306 | 34879.4 | 1 | UniProt (P08581) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | HGF RECEPTOR, 2.7.10.1, HGF/SF RECEPTOR, PROTO-ONCOGENE C-MET, SCATTER FACTOR RECEPTOR, SF RECEPTOR, TYROSINE-PROTEIN KINASE MET |
| 2 | B (A) | 4-[3-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-6-yl]benzenecarbonitrile | non-polymer | 352.4 | 1 | Chemie (4K0) | |||
| 3 | C (A) | water | water | 18.0 | 371 | Chemie (HOH) |
Sequence modifications
A: 1051 - 1348 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Met 1050 | - | expression tag |
| His 1349 | - | expression tag |
| His 1350 | - | expression tag |
| His 1351 | - | expression tag |
| His 1352 | - | expression tag |
| His 1353 | - | expression tag |
| His 1354 | - | expression tag |
| His 1355 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34879.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 352.4 | |
| All* | Total formula weight | 35231.8 |
