4ANX

Complexes of PI3Kgamma with isoform selective inhibitors.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM	polymer	980	112099.6	1	UniProt (P48736) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454)	HOMO SAPIENS (HUMAN)	PI3-KINASE SUBUNIT GAMMA, PI3K-GAMMA, PI3KGAMMA, PTDINS-3-KINASE SUBUNIT GAMMA, PHOSPHATIDYLINOSITOL-4\,5-BISPHOSPHATE 3-KINASE 110 KDA CATALYTIC SUBUNIT GAMMA, PTDINS-3-KINASE SUBUNIT P110-GAMMA, P110GAMMA, PHOSPHOINOSITIDE-3-KINASE CATALYTIC GAMMA POLYPEPTIDE, SERINE/THREONINE PROTEIN KINASE PIK3CG, P120-PI3K
2	B (A)	5-{3-[(4-{3-[4-(1-methylethyl)phenyl]pyrazin-2-yl}piperazin-1-yl)sulfonyl]phenyl}pyrimidin-2-amine	non-polymer		515.6	1	Chemie (534)
3	C (A)	water	water		18.0	34	Chemie (HOH)

Sequence modifications

A: 144 - 1102 (UniProt: P48736)

PDB	External Database	Details
Met 139	-	expression tag
Leu 140	-	expression tag
Leu 141	-	expression tag
Gly 142	-	expression tag
Ser 143	-	expression tag
Glu 1103	-	expression tag
Phe 1104	-	expression tag
Gly 1105	-	expression tag
Leu 1106	-	expression tag
Val 1107	-	expression tag
Pro 1108	-	expression tag
Arg 1109	-	expression tag
Gly 1110	-	expression tag
Ser 1111	-	expression tag
Gly 1112	-	expression tag
His 1113	-	expression tag
His 1114	-	expression tag
His 1115	-	expression tag
His 1116	-	expression tag
His 1117	-	expression tag
His 1118	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	112099.6
Non-Polymers*	Number of molecules	1
	Total formula weight	515.6
All*	Total formula weight	112615.2

*Water molecules are not included.