4ANU
Complexes of PI3Kgamma with isoform selective inhibitors.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM | polymer | 980 | 112098.7 | 1 | UniProt (P48736) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | HOMO SAPIENS (HUMAN) | PI3-KINASE SUBUNIT GAMMA, PI3K-GAMMA, PI3KGAMMA, PTDINS-3-KINASE SUBUNIT GAMMA, PHOSPHATIDYLINOSITOL-4\,5-BISPHOSPHATE 3-KINASE 110 KDA CATALYTIC SUBUNIT GAMMA, PTDINS-3-KINASE SUBUNIT P110-GAMMA, P110GAMMA, PHOSPHOINOSITIDE-3-KINASE CATALYTIC GAMMA POLYPEPTIDE, SERINE/THREONINE PROTEIN KINASE PIK3CG, P120-PI3K |
2 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
3 | A | 3-AMINO-N-METHYL-6-[3-(1H-TETRAZOL-5-YL)PHENYL]PYRAZINE-2-CARBOXAMIDE | non-polymer | 296.3 | 1 | Chemie (EM7) | |||
4 | water | water | 18.0 | 26 | Chemie (HOH) |
Sequence modifications
A: 144 - 1102 (UniProt: P48736)
PDB | External Database | Details |
---|---|---|
Met 139 | - | expression tag |
Leu 140 | - | expression tag |
Leu 141 | - | expression tag |
Gly 142 | - | expression tag |
Ser 143 | - | expression tag |
Glu 1103 | - | expression tag |
Phe 1104 | - | expression tag |
Gly 1105 | - | expression tag |
Leu 1106 | - | expression tag |
Val 1107 | - | expression tag |
Pro 1108 | - | expression tag |
Arg 1109 | - | expression tag |
Gly 1110 | - | expression tag |
Ser 1111 | - | expression tag |
Gly 1112 | - | expression tag |
His 1113 | - | expression tag |
His 1114 | - | expression tag |
His 1115 | - | expression tag |
His 1116 | - | expression tag |
His 1117 | - | expression tag |
His 1118 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 112098.7 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 392.3 | |
All* | Total formula weight | 112491.0 |