4ANQ

Structure of G1269A Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	ALK TYROSINE KINASE RECEPTOR	polymer	342	38610.1	1	UniProt (Q9UM73) Pfam (PF07714)	HOMO SAPIENS (HUMAN)	ANAPLASTIC LYMPHOMA KINASE, CD246
2	B (A)	3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine	non-polymer		450.3	1	Chemie (VGH)
3	C (A)	water	water		18.0	209	Chemie (HOH)

Sequence modifications

A: 1093 - 1411 (UniProt: Q9UM73)

PDB	External Database	Details
Met 1070	-	expression tag
Ala 1071	-	expression tag
His 1072	-	expression tag
His 1073	-	expression tag
His 1074	-	expression tag
His 1075	-	expression tag
His 1076	-	expression tag
His 1077	-	expression tag
Asp 1078	-	expression tag
Tyr 1079	-	expression tag
Gly 1080	-	expression tag
Ile 1081	-	expression tag
Pro 1082	-	expression tag
Thr 1083	-	expression tag
Thr 1084	-	expression tag
Glu 1085	-	expression tag
Asn 1086	-	expression tag
Leu 1087	-	expression tag
Tyr 1088	-	expression tag
Phe 1089	-	expression tag
Gln 1090	-	expression tag
Gly 1091	-	expression tag
Ser 1092	-	expression tag
Ala 1269	Gly 1269	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	38610.1
Non-Polymers*	Number of molecules	1
	Total formula weight	450.3
All*	Total formula weight	39060.5

*Water molecules are not included.