4AJF
Identification and structural characterization of PDE10 fragment inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, D) | CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE 10A | polymer | 328 | 37934.6 | 2 | UniProt (Q9Y233) | HOMO SAPIENS (HUMAN) | PDE10, PHOSPHODIESTERASE 10A |
| 2 | C, F (A, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, G (A, D) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E (A) | N-(4-OXO-3H-QUINAZOLIN-2-YL)ACETAMIDE | non-polymer | 203.2 | 1 | Chemie (F03) | |||
| 5 | H, I (A, D) | water | water | 18.0 | 369 | Chemie (HOH) |
Sequence modifications
A, D: 449 - 774 (UniProt: Q9Y233)
| PDB | External Database | Details |
|---|---|---|
| Asn 447 | - | expression tag |
| Ala 448 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75869.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 382.6 | |
| All* | Total formula weight | 76251.8 |
