4AGC

CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH AXITINIB (AG-013736) (N-Methyl-2-(3-((E)-2-pyridin-2-yl- vinyl)-1H-indazol-6-ylsulfanyl)-benzamide)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	polymer	353	40258.4	1	UniProt (P35968) Pfam (PF07714)	HOMO SAPIENS (HUMAN)	VEGFR-2, FETAL LIVER KINASE 1, FLK-1, KINASE INSERT DOMAIN RECEPTOR, KDR, PROTEIN-TYROSINE KINASE RECEPTOR FLK-1, CD309
2	B (A)	AXITINIB	non-polymer		386.5	1	Chemie (AXI)
3	C (A)	water	water		18.0	151	Chemie (HOH)

Sequence modifications

A: 787 - 939 (UniProt: P35968)

PDB	External Database	Details
Met 769	-	expression tag
Gly 770	-	expression tag
Gly 771	-	expression tag
His 772	-	expression tag
His 773	-	expression tag
His 774	-	expression tag
His 775	-	expression tag
His 776	-	expression tag
His 777	-	expression tag
Gly 778	-	expression tag
Leu 779	-	expression tag
Glu 780	-	expression tag
Val 781	-	expression tag
Leu 782	-	expression tag
Phe 783	-	expression tag
Gln 784	-	expression tag
Gly 785	-	expression tag
Pro 786	-	expression tag

A: 990 - 1171 (UniProt: P35968)

PDB	External Database	Details
Val 990	Glu 990	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	40258.4
Non-Polymers*	Number of molecules	1
	Total formula weight	386.5
All*	Total formula weight	40644.9

*Water molecules are not included.