4A9H

N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-(2-methyl-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	BROMODOMAIN-CONTAINING PROTEIN 2	polymer	154	17908.7	3	UniProt (P25440) Pfam (PF00439)	HOMO SAPIENS (HUMAN)	HUMAN BRD2
2	D, E (A)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
3	F, H, I (A, B, C)	(2S)-1-ACETYL-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE	non-polymer		189.3	3	Chemie (TVP)
4	G, J (A, C)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
5	K, L, M (A, B, C)	water	water		18.0	320	Chemie (HOH)

Sequence modifications

A, B, C: 67 - 200 (UniProt: P25440)

PDB	External Database	Details
Gly 47	-	expression tag
Ser 48	-	expression tag
Ser 49	-	expression tag
His 50	-	expression tag
His 51	-	expression tag
His 52	-	expression tag
His 53	-	expression tag
His 54	-	expression tag
His 55	-	expression tag
Ser 56	-	expression tag
Ser 57	-	expression tag
Gly 58	-	expression tag
Leu 59	-	expression tag
Val 60	-	expression tag
Pro 61	-	expression tag
Arg 62	-	expression tag
Gly 63	-	expression tag
Ser 64	-	expression tag
His 65	-	expression tag
Met 66	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	53726.2
Non-Polymers*	Number of molecules	7
	Total formula weight	884.0
All*	Total formula weight	54610.2

*Water molecules are not included.