4A16
Structure of mouse Acetylcholinesterase complex with Huprine derivative
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | ACETYLCHOLINESTERASE | polymer | 545 | 59890.6 | 4 | UniProt (P21836) Pfam (PF00135) | MUS MUSCULUS (HOUSE MOUSE) | ACHE |
| 2 | E, K, R, X (A, B, C, D) | (1-{4-[(7S,11S)-12-AMINO-3-CHLORO-6,7,10,11-TETRAHYDRO-7,11-METHANOCYCLOOCTA[B]QUINOLIN-9-YL]BUTYL}-1H-1,2,3-TRIAZOL-4-YL)METHANOL | non-polymer | 423.9 | 4 | Chemie (H34) | |||
| 3 | AA, BA, F, G, H... (D, A, B, C) | SULFATE ION | non-polymer | 96.1 | 14 | Chemie (SO4) | |||
| 4 | I, J, Q, V, W (A, B, C) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 5 | L (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | CA, DA, EA, FA (A, B, C, D) | water | water | 18.0 | 2323 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 4 - 543 (UniProt: P21836)
| PDB | External Database | Details |
|---|---|---|
| Ala 544 | - | expression tag |
| Thr 545 | - | expression tag |
| Glu 546 | - | expression tag |
| Ala 547 | - | expression tag |
| Pro 548 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 239562.5 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 3439.1 | |
| All* | Total formula weight | 243001.6 |
