4A07
Human PDK1 Kinase Domain in Complex with Allosteric Activator PS171 Bound to the PIF-Pocket
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 | polymer | 311 | 35424.6 | 1 | UniProt (O15530) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | HPDK1 |
| 2 | B (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 3 | C, D (A) | (3S)-3-(4-CHLOROPHENYL)-4-(5,7-DICHLORO-1H-BENZIMIDAZOL-2-YL)BUTANOIC ACID | non-polymer | 383.7 | 2 | Chemie (AZ7) | |||
| 4 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | F, G, H, I, J (A) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 6 | K (A) | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A: 50 - 359 (UniProt: O15530)
| PDB | External Database | Details |
|---|---|---|
| Gly 49 | - | expression tag |
| Gly 288 | Tyr 288 | engineered mutation |
| Ala 292 | Gln 292 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35424.6 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1476.1 | |
| All* | Total formula weight | 36900.7 |
