44IV

KIR2DS4 bound to HLA-C*05:01 presenting the P2-AW peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (A, E)	HLA class I histocompatibility antigen, C alpha chain	polymer	279	32366.8	2	UniProt (P10321)	Homo sapiens (human)	HLA-C,HLA-Cw,Human leukocyte antigen C
2	B, F (B, F)	Beta-2-microglobulin	polymer	100	11879.4	2	UniProt (P61769)	Homo sapiens (human)
3	C, G (C, G)	P2-AW peptide	polymer	9	989.1	2		synthetic construct
4	D, H (D, H)	Killer cell immunoglobulin-like receptor 2DS4	polymer	198	21828.6	2	UniProt (P43632)	Homo sapiens (human)	CD158 antigen-like family member I,Natural killer-associated transcript 8,NKAT-8,P58 natural killer cell receptor clones CL-39/CL-17,p58 NK receptor CL-39/CL-17
5	I, J, K, L, M... (A, D, E, F, H)	SULFATE ION	non-polymer		96.1	13	Chemie (SO4)
6	AA, BA, CA, V, W... (F, G, H, A, B...)	water	water		18.0	453	Chemie (HOH)

Sequence modifications

A, E: 2 - 278 (UniProt: P10321)

PDB	External Database	Details
Met 0	-	initiating methionine
Met 1	-	expression tag
Tyr 9	Asp 33	variant
Ala 24	Ser 48	variant
Gln 35	Arg 59	variant
Thr 73	Ala 97	variant
Asn 77	Ser 101	variant
Lys 80	Asn 104	variant
Ala 90	Asp 114	variant
Tyr 99	Ser 123	variant
Asn 114	Asp 138	variant
Phe 116	Ser 140	variant
Lys 138	Thr 162	variant
Trp 147	Leu 171	variant
Glu 152	Ala 176	variant
Arg 156	Leu 180	variant
Lys 177	Glu 201	variant
His 184	Pro 208	variant
Val 194	Leu 218	variant
Glu 253	Gln 277	variant
Val 261	Met 285	variant
Pro 267	Gln 291	variant
Arg 273	Ser 297	variant
Gly 275	Glu 299	variant

B, F: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
Met 0	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	134127.7
Non-Polymers*	Number of molecules	13
	Total formula weight	1248.8
All*	Total formula weight	135376.5

*Water molecules are not included.