3ZZE
Crystal structure of C-MET kinase domain in complex with N'-((3Z)-4- chloro-7-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-(4- hydroxyphenyl)propanohydrazide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HEPATOCYTE GROWTH FACTOR RECEPTOR | polymer | 306 | 34879.4 | 1 | UniProt (P08581) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | HGF RECEPTOR, HGF/SF RECEPTOR, PROTO-ONCOGENE C-MET, SCATTER FACTOR RECEPTOR, SF RECEPTOR, TYROSINE-PROTEIN KINASE MET |
| 2 | B (A) | (2S)-N'-[(3R)-4-chloro-7-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl]-2-(4-hydroxyphenyl)propanehydrazide | non-polymer | 359.8 | 1 | Chemie (6XP) | |||
| 3 | C (A) | water | water | 18.0 | 235 | Chemie (HOH) |
Sequence modifications
A: 1051 - 1348 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Met 1050 | - | expression tag |
| His 1349 | - | expression tag |
| His 1350 | - | expression tag |
| His 1351 | - | expression tag |
| His 1352 | - | expression tag |
| His 1353 | - | expression tag |
| His 1354 | - | expression tag |
| His 1355 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34879.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 359.8 | |
| All* | Total formula weight | 35239.2 |
