3ZZC
Crystal structure of 3C protease mutant (T68A and N126Y) of coxsackievirus B3 complexed with alpha, beta-unsaturated ethyl ester inhibitor 83
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 3C PROTEINASE | polymer | 183 | 20317.3 | 1 | UniProt (Q90092) Pfam (PF00548) UniProt (by SIFTS) (Q5UEA2) | HUMAN COXSACKIEVIRUS | POLYPROTEIN 3BCD |
| 2 | B (A) | ETHYL (5S,8S,11R)-8-BENZYL-5-(2-TERT-BUTOXY-2-OXOETHYL)-3,6,9-TRIOXO-11-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}-1-PHENYL-2-OXA-4,7,10-TRIAZATETRADECAN-14-OATE | non-polymer | 680.8 | 1 | Chemie (G83) | |||
| 3 | C (A) | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
A: 1 - 183 (UniProt: Q90092)
| PDB | External Database | Details |
|---|---|---|
| Ala 68 | Thr 81 | engineered mutation |
| Tyr 126 | Asn 139 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 20317.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 680.8 | |
| All* | Total formula weight | 20998.1 |
