3ZYX
Crystal structure of human monoamine oxidase B in complex with methylene blue and bearing the double mutation I199A-Y326A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | AMINE OXIDASE [FLAVIN-CONTAINING] B | polymer | 519 | 58572.4 | 2 | UniProt (P27338) Pfam (PF01593) | HOMO SAPIENS (HUMAN) | MONOAMINE OXIDASE B, MONOAMINE OXIDASE TYPE B, MAO-B |
| 2 | C, E (A, B) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 2 | Chemie (FAD) | |||
| 3 | D, F (A, B) | 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM | non-polymer | 284.4 | 2 | Chemie (MBT) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 350 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 520 (UniProt: P27338)
| PDB | External Database | Details |
|---|---|---|
| Ala 199 | Ile 199 | engineered mutation |
| Ala 326 | Tyr 326 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 117144.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2139.9 | |
| All* | Total formula weight | 119284.6 |
