3ZYU
Crystal Structure of the first bromodomain of human BRD4 in complex with I-BET151(GSK1210151A)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | BROMODOMAIN-CONTAINING PROTEIN 4 | polymer | 127 | 15099.4 | 2 | UniProt (O60885) Pfam (PF00439) | HOMO SAPIENS (HUMAN) | HUMAN BRD4, PROTEIN HUNK1 |
| 2 | C, D, E, F, H... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 3 | G, K (A, B) | 7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-8-METHOXY-1-[(1R)-1-(PYRIDIN-2-YL)ETHYL]-1H,2H,3H-IMIDAZO[4,5-C]QUINOLIN-2-ONE | non-polymer | 415.4 | 2 | Chemie (1GH) | |||
| 4 | L, M (A, B) | water | water | 18.0 | 412 | Chemie (HOH) |
Sequence modifications
A, B: 44 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Ser 42 | - | expression tag |
| Met 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30198.8 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1265.4 | |
| All* | Total formula weight | 31464.1 |
