3ZUR
Crystal structure of an engineered botulinum neurotoxin type A- SNARE23 derivative, LC0-A-SNAP25-Hn-A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | BOTULINUM NEUROTOXIN TYPE A, SYNAPTOSOMAL-ASSOCIATED PROTEIN | polymer | 960 | 108570.0 | 2 | UniProt (P10845) UniProt (P60880) Pfam (PF01742) Pfam (PF07952) UniProt (by SIFTS) (P0DPI1) | CLOSTRIDIUM BOTULINUM | LC-A0-SNAP25-HN-A, BONT/A, BONTOXILYSIN-A, BOTOX, BOTULINUM NEUROTOXIN A LIGHT CHAIN, BOTULINUM NEUROTOXIN A HEAVY CHAIN, SNAP-25, SUPER PROTEIN, SUP, SYNAPTOSOMAL-ASSOCIATED 25 KDA PROTEIN |
| 2 | C, D, E, F, G (A, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 3 | H, I (A, B) | water | water | 18.0 | 149 | Chemie (HOH) |
Sequence modifications
A, B: 3 - 431 (UniProt: P10845)
A, B: 533 - 944 (UniProt: P10845)
A, B: 448 - 509 (UniProt: P60880)
| PDB | External Database | Details |
|---|---|---|
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Met 1 | - | expression tag |
| Glu 2 | - | expression tag |
| Ala 27 | Val 27 | variant |
| Gln 224 | Glu 224 | engineered mutation |
| Tyr 227 | His 227 | engineered mutation |
| Val 431 | - | linker |
| Leu 945 | - | expression tag |
| Glu 946 | - | expression tag |
| Ala 947 | - | expression tag |
| His 948 | - | expression tag |
| His 949 | - | expression tag |
| His 950 | - | expression tag |
| His 951 | - | expression tag |
| His 952 | - | expression tag |
| His 953 | - | expression tag |
| His 954 | - | expression tag |
| His 955 | - | expression tag |
| His 956 | - | expression tag |
| His 957 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp 432 | - | linker |
| Gly 433 | - | linker |
| Gly 434 | - | linker |
| Gly 435 | - | linker |
| Gly 436 | - | linker |
| Ser 437 | - | linker |
| Gly 438 | - | linker |
| Gly 439 | - | linker |
| Gly 440 | - | linker |
| Gly 441 | - | linker |
| Ser 442 | - | linker |
| Gly 443 | - | linker |
| Gly 444 | - | linker |
| Gly 445 | - | linker |
| Gly 446 | - | linker |
| Ser 447 | - | linker |
| Ala 510 | - | linker |
| Asn 511 | - | linker |
| Ser 512 | - | linker |
| Ala 513 | - | linker |
| Leu 514 | - | linker |
| Ala 515 | - | linker |
| Gly 516 | - | linker |
| Gly 517 | - | linker |
| Gly 518 | - | linker |
| Gly 519 | - | linker |
| Ser 520 | - | linker |
| Gly 521 | - | linker |
| Gly 522 | - | linker |
| Gly 523 | - | linker |
| Gly 524 | - | linker |
| Ser 525 | - | linker |
| Gly 526 | - | linker |
| Gly 527 | - | linker |
| Gly 528 | - | linker |
| Gly 529 | - | linker |
| Ser 530 | - | linker |
| Leu 531 | - | linker |
| Gln 532 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 217140.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 480.3 | |
| All* | Total formula weight | 217620.3 |
