3ZUN

pVHL54-213-EloB-EloC complex_(2S,4R)-4-hydroxy-1-(2-(3-methylisoxazol- 5-yl)acetyl)-N-(4-nitrobenzyl)pyrrolidine-2-carboxamide bound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J	TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2	polymer	118	13147.8	4	UniProt (Q15370) Pfam (PF00240) In PDB	HOMO SAPIENS (HUMAN)	ELONGIN 18 KDA SUBUNIT, ELONGIN-B, ELOB, RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT B, SIII P18
2	B, E, H, K	TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1	polymer	97	10974.6	4	UniProt (Q15369) Pfam (PF03931) In PDB	HOMO SAPIENS (HUMAN)	ELONGIN 15 KDA SUBUNIT, ELONGIN-C, ELOC, RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT C, SIII P15
3	C, F, I, L	VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR	polymer	163	18840.4	4	UniProt (P40337) Pfam (PF01847) Pfam (PF17211) In PDB	HOMO SAPIENS (HUMAN)	PROTEIN G7, PVHL
4	B	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5	C, F, I, L	(4R)-N-[4-(DIHYDROXYAMINO)BENZYL]-4-HYDROXY-1-[(3-METHYLISOXAZOL-5-YL)ACETYL]-L-PROLINAMIDE	non-polymer		390.4	4	Chemie (ZUN)
6		water	water		18.0	223	Chemie (HOH)

Sequence modifications

B, E, H, K: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	expression tag

C, F, I, L: 54 - 213 (UniProt: P40337)

PDB	External Database	Details
Gly 51	-	expression tag
Ser 52	-	expression tag
His 53	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	171851.3
Non-Polymers*	Number of molecules	5
	Total formula weight	1653.7
All*	Total formula weight	173505.0

*Water molecules are not included.