3ZTD
pVHL54-213-EloB-EloC complex _ methyl 4-(((2S,4R)-4-hydroxy-1-(2-(3- methylisoxazol-5-yl)acetyl)pyrrolidine-2-carboxamido)methyl)benzoate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, J (A, D, G, J) | TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2 | polymer | 118 | 13147.8 | 4 | UniProt (Q15370) Pfam (PF00240) | HOMO SAPIENS (HUMAN) | ELONGIN 18 KDA SUBUNIT, ELONGIN-B, ELOB, RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT B, SIII P18, ELONGINB |
| 2 | B, E, H, K (B, E, H, K) | TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1 | polymer | 97 | 10974.6 | 4 | UniProt (Q15369) Pfam (PF03931) | HOMO SAPIENS (HUMAN) | ELONGIN 15 KDA SUBUNIT, ELONGIN-C, ELOC, RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT C, SIII P15, ELONGINC |
| 3 | C, F, I, L (C, F, I, L) | VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR | polymer | 162 | 18702.3 | 4 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | HOMO SAPIENS (HUMAN) | PROTEIN G7, PVHL |
| 4 | M, N, O, P (C, F, I, L) | METHYL 4-[({(4R)-4-HYDROXY-1-[(3-METHYLISOXAZOL-5-YL)ACETYL]-L-PROLYL}AMINO)METHYL]BENZOATE | non-polymer | 401.4 | 4 | Chemie (ZTD) | |||
| 5 | Q, R, S, T, U... (A, C, F, I, J...) | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
B, E, H, K: 17 - 112 (UniProt: Q15369)
C, F, I, L: 54 - 213 (UniProt: P40337)
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 171298.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1605.7 | |
| All* | Total formula weight | 172904.4 |
