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3ZSI

X-ray structure of p38alpha bound to VX-745

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AMITOGEN-ACTIVATED PROTEIN KINASE 14polymer36241494.31UniProt (Q16539)
Pfam (PF00069)
In PDB
HOMO SAPIENS (HUMAN)MAP KINASE 14, MAPK 14, CYTOKINE SUPPRESSIVE ANTI-INFLAMMATORY DRUG-BINDING PROTEIN, CSAID-BINDING PROTEIN, CSBP, MAP KINASE MXI2, MAX-INTERACTING PROTEIN 2, MITOGEN-ACTIVATED PROTEIN KINASE P38 ALPHA, MAP KINASE P38 ALPHA, SAPK2A, P38A
2A5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-onenon-polymer436.31Chemie (52P)
3Aoctyl beta-D-glucopyranosidenon-polymer292.41Chemie (BOG)
4waterwater18.0130Chemie (HOH)
Sequence modifications
A: 2 - 360 (UniProt: Q16539)
PDBExternal DatabaseDetails
Gly -1-expression tag
Ser 0-expression tag
His 1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight41494.3
Non-Polymers*Number of molecules2
Total formula weight728.6
All*Total formula weight42222.9
*Water molecules are not included.

222036

PDB entries from 2024-07-03

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