3ZS2
TyrB25,NMePheB26,LysB28,ProB29-insulin analogue crystal structure
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G, I... | INSULIN A CHAIN | polymer | 21 | 2383.7 | 6 | UniProt (P01308) In PDB | HOMO SAPIENS | |
| 2 | B, D, F, H, J... | INSULIN B CHAIN | polymer | 30 | 3448.0 | 6 | UniProt (P01308) Pfam (PF00049) In PDB | HOMO SAPIENS | |
| 3 | A, C, E, G, I... | PHENOL | non-polymer | 94.1 | 6 | Chemie (IPH) | |||
| 4 | B, C | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | B, D | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | water | water | 18.0 | 150 | Chemie (HOH) |
Sequence modifications
B, D, F, H, J, L: 1 - 30 (UniProt: P01308)
| PDB | External Database | Details |
|---|---|---|
| Tyr 25 | Phe 49 | engineered mutation |
| Mea 26 | Tyr 50 | engineered mutation |
| Lys 28 | Pro 52 | engineered mutation |
| Pro 29 | Lys 53 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 34990.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 766.4 | |
| All* | Total formula weight | 35756.5 |
