3ZRL
Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | GLYCOGEN SYNTHASE KINASE-3 BETA | polymer | 371 | 42036.1 | 2 | UniProt (P49841) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | GSK-3 BETA |
| 2 | C, D (X, Y) | PROTO-ONCOGENE FRAT1 | polymer | 32 | 3772.4 | 2 | UniProt (Q92837) | HOMO SAPIENS (HUMAN) | FREQUENTLY REARRANGED IN ADVANCED T-CELL LYMPHOMAS 1, FRAT |
| 3 | E, F, G, J, K... (A, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 4 | H, M, N (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | I, O (A, B) | 7-BROMO-2-PYRIDIN-4-YL-5H-THIENO[3,2-C]PYRIDIN-4-ONE | non-polymer | 307.2 | 2 | Chemie (ZRL) | |||
| 6 | P, Q, R, S (A, B, X, Y) | water | water | 18.0 | 198 | Chemie (HOH) |
Sequence modifications
X, Y: 197 - 226 (UniProt: Q92837)
| PDB | External Database | Details |
|---|---|---|
| Met 195 | - | expression tag |
| Ala 196 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 91617.1 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1467.0 | |
| All* | Total formula weight | 93084.1 |
