3ZOS
Structure of the DDR1 kinase domain in complex with ponatinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1 | polymer | 315 | 35754.1 | 2 | UniProt (Q08345) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | EPITHELIAL DISCOIDIN DOMAIN RECEPTOR, CD167 ANTIGEN-LIKE FAMILY MEMBER A, CELL ADHESION KINASE, DISCOIDIN RECEPTOR TYROSINE KINASE, HGK2, MAMMARY CARCINOMA KINASE 10, MCK-10, PROTEIN-TYROSINE KINASE 3A, PROTEIN-TYROSINE KINASE RTK-6, TRK E, TYROSINE KINASE DDR, TYROSINE-PROTEIN KINASE CAK, CD167A |
| 2 | C, F, G (A, B) | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide | non-polymer | 532.6 | 3 | Chemie (0LI) | |||
| 3 | D, E, H (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 336 | Chemie (HOH) |
Sequence modifications
A, B: 601 - 913 (UniProt: Q08345)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Met 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71508.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1783.9 | |
| All* | Total formula weight | 73292.1 |
