3ZO4
The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA | polymer | 351 | 40837.6 | 1 | UniProt (P00517) Pfam (PF00069) | BOS TAURUS (BOVINE) | PKA C-ALPHA |
| 2 | B (I) | CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA | polymer | 20 | 2226.4 | 1 | UniProt (Q3SX13) | BOS TAURUS | PKI-ALPHA |
| 3 | C (A) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
| 4 | D (A) | 6-(4-PHENYL-1,9-DIAZASPIRO[5.5]UNDECAN-9-YL)-9H-PURINE | non-polymer | 348.4 | 1 | Chemie (QWI) | |||
| 5 | E (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | F (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 7 | G, H (A, I) | water | water | 18.0 | 447 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43064.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 636.8 | |
| All* | Total formula weight | 43700.9 |
