3ZLW
Crystal structure of MEK1 in complex with fragment 3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 MAPK/ERK KINASE 1, MEK 1, MEK1 | polymer | 348 | 38948.9 | 1 | UniProt (Q02750) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | |
| 2 | B (A) | (1R)-1-hydroxy-1-methyl-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-5-one | non-polymer | 217.3 | 1 | Chemie (MT8) PubChem (3694944) | |||
| 3 | C (A) | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
A: 37 - 383 (UniProt: Q02750)
| PDB | External Database | Details |
|---|---|---|
| Gly 36 | - | expression tag |
| Ala 77 | Gly 77 | conflict |
| Asn 298 | Ser 298 | engineered mutation |
| Lys 299 | Ser 299 | engineered mutation |
| Phe 300 | Tyr 300 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38948.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 217.3 | |
| All* | Total formula weight | 39166.2 |
