3ZLR
Crystal structure of BCL-XL in complex with inhibitor (WEHI-539)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | BCL-2-LIKE PROTEIN 1 | polymer | 158 | 17918.0 | 2 | UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) | HOMO SAPIENS (HUMAN) | BCL2-L-1, APOPTOSIS REGULATOR BCL-X, BCL-XL |
| 2 | C, G (A, B) | 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid | non-polymer | 583.7 | 2 | Chemie (X0B) | |||
| 3 | D, E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | F, H, I (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 5 | J, K (A, B) | water | water | 18.0 | 262 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 26 (UniProt: Q07817)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35835.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1579.8 | |
| All* | Total formula weight | 37415.7 |
