3ZKX
TERNARY BACE2 XAPERONE COMPLEX
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | BETA-SECRETASE 2 | polymer | 386 | 42047.4 | 1 | UniProt (Q9Y5Z0) Pfam (PF00026) | HOMO SAPIENS (HUMAN) | ASPARTIC-LIKE PROTEASE 56 KDA, ASPARTYL PROTEASE 1, ASP1, ASP 1, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 2, BETA-SITE APP CLEAVING ENZYME 2, DOWN REGION ASPARTIC PROTEASE, DRAP, MEMAPSIN-1, MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 1, THETA-SECRETASE, BACE2 |
| 2 | B (B) | XA4813 | polymer | 122 | 13152.5 | 1 | LAMA GLAMA (LLAMA) | ||
| 3 | C (C) | XA4815 | polymer | 122 | 13406.8 | 1 | LAMA GLAMA (LLAMA) | ||
| 4 | D (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | E (B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 6 | F, G, H (A, B, C) | water | water | 18.0 | 311 | Chemie (HOH) |
Sequence modifications
A: 13 - 398 (UniProt: Q9Y5Z0)
| PDB | External Database | Details |
|---|---|---|
| Ala 269 | Glu 1195 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 68606.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 113.6 | |
| All* | Total formula weight | 68720.3 |
