3ZKI
BACE2 MUTANT STRUCTURE WITH LIGAND
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | BETA-SECRETASE 2 | polymer | 386 | 42047.4 | 2 | UniProt (Q9Y5Z0) Pfam (PF00026) | HOMO SAPIENS (HUMAN) | ASPARTIC-LIKE PROTEASE 56 KDA, ASPARTYL PROTEASE 1, ASP1, ASP 1, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 2, BETA-SITE APP CLEAVING ENZYME 2, DOWN REGION ASPARTIC PROTEASE, DRAP, MEMAPSIN-1, MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 1, THETA-SECRETASE, BACE2 |
| 2 | C, D (A, B) | 5-(2,2,2-Trifluoro-ethoxy)-pyridine-2-carboxylic acid [3-((S)-2-amino-1,4-dimethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-4-yl)-phenyl]-amide | non-polymer | 435.4 | 2 | Chemie (WZV) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 248 | Chemie (HOH) |
Sequence modifications
A, B: 13 - 398 (UniProt: Q9Y5Z0)
| PDB | External Database | Details |
|---|---|---|
| Ala 269 | Glu 331 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 84094.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 870.8 | |
| All* | Total formula weight | 84965.5 |
