3ZGD

crystal structure of a KEAP1 mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	KELCH-LIKE ECH-ASSOCIATED PROTEIN 1	polymer	310	33840.8	2	UniProt (Q14145) Pfam (PF01344)	HOMO SAPIENS (HUMAN)	CYTOSOLIC INHIBITOR OF NRF2, INRF2, KELCH-LIKE PROTEIN 19
2	C, D, E, F, H... (A, B)	ACETATE ION	non-polymer		59.0	10	Chemie (ACT)
3	G (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
4	N, O (A, B)	water	water		18.0	667	Chemie (HOH)

Sequence modifications

A, B: 321 - 609 (UniProt: Q14145)

PDB	External Database	Details
Met 300	-	expression tag
Gly 301	-	expression tag
Ser 302	-	expression tag
Ser 303	-	expression tag
His 304	-	expression tag
His 305	-	expression tag
His 306	-	expression tag
His 307	-	expression tag
His 308	-	expression tag
His 309	-	expression tag
Ser 310	-	expression tag
Ser 311	-	expression tag
Gly 312	-	expression tag
Leu 313	-	expression tag
Val 314	-	expression tag
Pro 315	-	expression tag
Arg 316	-	expression tag
Gly 317	-	expression tag
Ser 318	-	expression tag
His 319	-	expression tag
Met 320	-	expression tag
Ala 540	Glu 540	engineered mutation
Ala 542	Glu 542	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	67681.7
Non-Polymers*	Number of molecules	11
	Total formula weight	613.4
All*	Total formula weight	68295.1

*Water molecules are not included.