3ZBL
Crystal structure of SCP2 thiolase from Leishmania mexicana: The C123S mutant.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 3-KETOACYL-COA THIOLASE-LIKE PROTEIN | polymer | 457 | 49241.9 | 2 | UniProt (E9AW84) Pfam (PF00108) Pfam (PF22691) | LEISHMANIA MEXICANA | SCP2 THIOLASE |
| 2 | C, S (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 3 | D, E, F, G, H... (A, B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 15 | Chemie (DMS) | |||
| 4 | M, O, Q, W (A, B) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 4 | Chemie (MPD) | |||
| 5 | X, Y (A, B) | water | water | 18.0 | 650 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 441 (UniProt: E9AW84)
| PDB | External Database | Details |
|---|---|---|
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Leu 6 | Met 6 | SEE REMARK 999 |
| Ala 12 | Thr 12 | SEE REMARK 999 |
| Pro 31 | Lys 31 | SEE REMARK 999 |
| Ile 34 | Val 34 | SEE REMARK 999 |
| Lys 45 | Gln 45 | SEE REMARK 999 |
| Gly 59 | His 59 | SEE REMARK 999 |
| Met 61 | Ile 61 | SEE REMARK 999 |
| His 63 | Asn 63 | SEE REMARK 999 |
| Ser 64 | Val 64 | SEE REMARK 999 |
| Gly 65 | Ser 65 | SEE REMARK 999 |
| Ser 67 | Lys 67 | SEE REMARK 999 |
| Arg 69 | Lys 69 | SEE REMARK 999 |
| Gly 71 | Asp 71 | SEE REMARK 999 |
| Ser 107 | Ala 107 | SEE REMARK 999 |
| Met 112 | Ile 112 | SEE REMARK 999 |
| Ser 123 | Cys 123 | engineered mutation |
| Met 134 | Thr 134 | SEE REMARK 999 |
| Ser 139 | Ala 139 | SEE REMARK 999 |
| Thr 145 | Val 145 | SEE REMARK 999 |
| Ser 157 | Thr 157 | SEE REMARK 999 |
| Gln 176 | Lys 176 | SEE REMARK 999 |
| Thr 229 | Ser 229 | SEE REMARK 999 |
| Val 268 | Ala 268 | SEE REMARK 999 |
| Arg 277 | Lys 277 | SEE REMARK 999 |
| Ile 327 | Val 327 | SEE REMARK 999 |
| Glu 356 | Asp 356 | SEE REMARK 999 |
| Asp 368 | Glu 368 | SEE REMARK 999 |
| Ile 398 | Val 398 | SEE REMARK 999 |
| Glu 410 | Gly 410 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 98483.9 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 1715.6 | |
| All* | Total formula weight | 100199.4 |
