3WYM

Crystal structure of the catalytic domain of PDE10A complexed with 1-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	polymer	338	38889.6	2	UniProt (Q9Y233)	Homo sapiens (human)
2	C, F (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	D, G (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	E, H (A, B)	1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one	non-polymer		428.4	2	Chemie (3K9)
5	I, J (A, B)	water	water		18.0	465	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	77779.2
Non-Polymers*	Number of molecules	6
	Total formula weight	1036.3
All*	Total formula weight	78815.4

*Water molecules are not included.