3WXF
Crystal structure of CYLD USP domain (C596S E674Q) in complex with Met1-linked diubiquitin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Uncharacterized protein | polymer | 312 | 35990.5 | 2 | UniProt (E7FEV5) Pfam (PF00443) | Danio rerio (zebra fish) | CYLD protein |
| 2 | B, D (B, D) | Ubiquitin | polymer | 148 | 16751.2 | 2 | UniProt (P0CG48) Pfam (PF00240) | Homo sapiens (human) | M1-linked diubiquitin |
| 3 | E, F (C) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 147 | Chemie (HOH) |
Sequence modifications
A, C: 578 - 780 (UniProt: E7FEV5)
A, C: 785 - 886 (UniProt: E7FEV5)
| PDB | External Database | Details |
|---|---|---|
| Ser 575 | - | expression tag |
| His 576 | - | expression tag |
| Met 577 | - | expression tag |
| Ser 596 | Cys 596 | engineered mutation |
| Gln 674 | Glu 674 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Leu 781 | - | linker |
| Glu 782 | - | linker |
| Gly 783 | - | linker |
| Gly 784 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 105483.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 192.1 | |
| All* | Total formula weight | 105675.6 |
